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Article

Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.

Infection and immunity - 1 Jan 2013

Hyams Catherine, Trzcinski Krzysztof, Camberlein Emilie, Weinberger Daniel M, Chimalapati Suneeta, Noursadeghi Mahdad, Lipsitch Marc, Brown Jeremy S

Abstract excerpt

Different capsular serotypes of Streptococcus pneumoniae vary markedly in their ability to cause invasive infection, but the reasons why are not known. As immunity to S. pneumoniae infection is highly complement dependent, variations in sensitivity to complement between S. pneumoniae capsular serotypes could affect invasiveness. We have used 20 capsule-switched variants of strain TIGR4 to investigate whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23147038
DOI: 10.1128/IAI.00862-12
PMCID: PMC3536142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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