Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Streptococcus pneumoniae PspC Subgroup Prevalence in Invasive Disease and Differences in Contribution to Complement Evasion.

Infection and immunity - 1 Apr 2018

van der Maten Erika, van den Broek Bryan, de Jonge Marien I, Rensen Kim J W, Eleveld Marc J, Zomer Aldert L, Cremers Amelieke J H, Ferwerda Gerben, de Groot Ronald, Langereis Jeroen D, van der Flier Michiel

Abstract excerpt

The pneumococcal capsular serotype is an important determinant of complement resistance and invasive disease potential, but other virulence factors have also been found to contribute. Pneumococcal surface protein C (PspC), a highly variable virulence protein that binds complement factor H to evade C3 opsonization, is divided into two subgroups: choline-bound subgroup I and LPxTG-anchored subgroup II. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Factor H
Share to Complement System Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Evasion

Share to Molecular Typing

Share to Pneumococcal Infections

Share to Serogroup

Share to Streptococcus pneumoniae

Share to Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29378798
DOI: 10.1128/IAI.00010-18
PMCID: PMC5865030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Streptococcus pneumoniae PspC Subgroup Prevalence in Invasive Disease and Differences in Contribution to Complement Evasion.PMID 29378798Read ↗

Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children.Semantic proximity Read ↗

The Effects of PspC on Complement-Mediated Immunity to <i>Streptococcus pneumoniae</i> Vary with Strain Background and Capsular SerotypeSemantic proximity Read ↗

Same, Same, but Different: Molecular Analyses of <i>Streptococcus pneumoniae</i> Immune Evasion Proteins Identifies new Domains and Reveals Structural Differences between PspC and Hic VariantsSemantic proximity Read ↗

Pneumococcal surface protein C group 4 of Streptococcus pneumoniae is a significant factor to human invasive pneumococcal diseasesSemantic proximity Read ↗

Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic.Semantic proximity Read ↗

The choline-binding proteins PspA, PspC and LytA of <i>Streptococcus pneumoniae</i> and their role on host cellular adhesion and damageSemantic proximity Read ↗

Factor H binding proteins protect division septa on encapsulated Streptococcus pneumoniae against complement C3b deposition and amplification.Semantic proximity Read ↗

Streptococcus pneumoniae capsular serotype invasiveness correlates with the degree of factor H binding and opsonization with C3b/iC3b.Semantic proximity Read ↗

The rise of serotype 8 is associated with lineages and mutations in the capsular operon with different potential to produce invasive pneumococcal diseaseSemantic proximity Read ↗

PspC, a Pneumococcal Surface Protein, Binds Human Factor HSemantic proximity Read ↗

Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion.Semantic proximity Read ↗

Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.