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The Capsular Serotype of<i>Streptococcus pneumoniae</i>Is More Important than the Genetic Background for Resistance to Complement

21 Sept 2010

Abstract excerpt

The polysaccharide capsule of Streptococcus pneumoniae inhibits phagocytic killing by innate immune mechanisms. Certain serotypes are associated with invasive disease while others with a nasopharyngeal carriage. The invasiveness of serotypes may partly be explained by ability to resist deposition of complement (C3) on the bacterial surface and consequent opsonophagocytic killing. In our previous studies, we...

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PMID: 20855513
DOI: 10.1128/iai.00740-10

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