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The Effects of PspC on Complement-Mediated Immunity to <i>Streptococcus pneumoniae</i> Vary with Strain Background and Capsular Serotype

3 Nov 2009

Abstract excerpt

Streptococcus pneumoniae may evade complement activity by binding of factor H (FH), a negative regulator of the alternative pathway, to the surface protein PspC. However, existing data on the effects of FH binding to PspC on complement activity are conflicting, and there is also considerable allelic variation in PspC structure between S. pneumoniae strains that may influence PspC-dependent effects on complement....

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PMID: 19884335
DOI: 10.1128/iai.00541-09

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