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Article

Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Dieudonné-Vatran Antoine, Krentz Stefanie, Blom Anna M, Meri Seppo, Henriques-Normark Birgitta, Riesbeck Kristian, Albiger Barbara

Abstract excerpt

The complement system constitutes an important component of the innate immune system. To colonize their host and/or to cause disease, many pathogens have evolved strategies to avoid complement-mediated bacterial lysis and opsonophagocytosis. In this study, using a collection of 55 clinical isolates of Streptococcus pneumoniae, we demonstrate for the first time that pneumococci bind the complement inhibitor...

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Identifiers

PMID: 19494311
DOI: 10.4049/jimmunol.0802376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion.PMID 19494311Read ↗

The Effects of PspC on Complement-Mediated Immunity to <i>Streptococcus pneumoniae</i> Vary with Strain Background and Capsular SerotypeSemantic proximity Read ↗

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Same, Same, but Different: Molecular Analyses of <i>Streptococcus pneumoniae</i> Immune Evasion Proteins Identifies new Domains and Reveals Structural Differences between PspC and Hic VariantsSemantic proximity Read ↗

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Molecular analyses identifies new domains and structural differences among Streptococcus pneumoniae immune evasion proteins PspC and Hic.Semantic proximity Read ↗

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