Article
Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence.
PloS one - 1 Jan 2011
Sanchez Carlos J, Hinojosa Cecilia A, Shivshankar Pooja, Hyams Catherine, Camberlein Emilie, Brown Jeremy S, Orihuela Carlos J
Abstract excerpt
We examined the contribution of serotype on Streptococcus pneumoniae adhesion and virulence during respiratory tract infection using a panel of isogenic TIGR4 (serotype 4) mutants expressing the capsule types 6A (+6A), 7F (+7F) and 23F (+23F) as well as a deleted and restored serotype 4 (+4) control strain. Immunoblots, bacterial capture assays with immobilized antibody, and measurement of mean fluorescent...
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