Article
Genomic Profiling Reveals Distinct Routes To Complement Resistance in Klebsiella pneumoniae.
Infection and immunity - 21 Jul 2020
Short Francesca L, Di Sario Gianna, Reichmann Nathalie T, Kleanthous Colin, Parkhill Julian, Taylor Peter W
Abstract excerpt
The serum complement system is a first line of defense against bacterial invaders. Resistance to killing by serum enhances the capacity of Klebsiella pneumoniae to cause infection, but it is an incompletely understood virulence trait. Identifying and characterizing the factors responsible for preventing activation of, and killing by, serum complement could inform new approaches to treatment of K. pneumoniae...
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