A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function.

doi:10.1523/JNEUROSCI.0542-04.2004

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Article

A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 May 2004

Wang Ping, Saraswati Sudipta, Guan Zhuo, Watkins Carol J, Wurtman Richard J, Littleton J Troy

Abstract excerpt

A novel paralytic mutant, nubian, was identified in a behavioral screen for conditional temperature-sensitive seizure mutants in Drosophila melanogaster. nubian mutants display reduced lifespan, abnormal motor behavior, altered synaptic structure, and defective neurotransmitter release. The nubian mutant disrupts phosphoglycerate kinase (PGK), an enzyme required for ATP generation in the terminal stage of the...

Topics

Adenosine Triphosphate
Animals
Behavior, Animal
Chromosome Mapping
Drosophila
Electrophysiology
Endocytosis
Female
Genetic Testing
Larva
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mutagenesis

Mutation

Oligonucleotide Array Sequence Analysis

Paralysis

Phosphoglycerate Kinase

SNARE Proteins

Source

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Identifiers

PMID: 15140922
DOI: 10.1523/JNEUROSCI.0542-04.2004
PMCID: PMC6729406

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