Article
Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 2003
Tabakoff Boris, Bhave Sanjiv V, Hoffman Paula L
Abstract excerpt
Acute functional tolerance to ethanol develops during a single exposure to ethanol; it has been suggested to be a predisposing factor for the development of ethanol dependence. Genetic determinants of acute functional tolerance, as well as of ethanol dependence, have been clearly demonstrated. We describe a novel approach that uses a combination of selective breeding (to segregate genes contributing to the...
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