Article
Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila.
Alcoholism, clinical and experimental research - 1 Feb 2010
Kong Eric C, Allouche Lorien, Chapot Paul A, Vranizan Karen, Moore Monica S, Heberlein Ulrike, Wolf Fred W
Abstract excerpt
BACKGROUND: Increased ethanol intake, a major predictor for the development of alcohol use disorders, is facilitated by the development of tolerance to both the aversive and pleasurable effects of the drug. The molecular mechanisms underlying ethanol tolerance development are complex and are not yet well understood. METHODS: To identify genetic mechanisms that contribute to ethanol tolerance, we examined the time...
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