Article
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.
The Journal of clinical investigation - 1 Dec 2012
Nishio Miki, Hamada Koichi, Kawahara Kohichi, Sasaki Masato, Noguchi Fumihito, Chiba Shuhei, Mizuno Kensaku, Suzuki Satoshi O, Dong Youyi, Tokuda Masaaki, Morikawa Takumi, Hikasa Hiroki, Eggenschwiler Jonathan, Yabuta Norikazu, Nojima Hiroshi, Nakagawa Kentaro, Hata Yutaka, Nishina Hiroshi, Mimori Koshi, Mori Masaki, Sasaki Takehiko, Mak Tak W, Nakano Toru, Itami Satoshi, Suzuki Akira
Abstract excerpt
Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling pathway and are mutated or inactivated in many human cancers. Here we show that intact Mob1a or Mob1b is essential for murine embryogenesis and that loss of the remaining WT Mob1 allele in Mob1a(Δ/Δ)1b(tr/+) or Mob1a(Δ/+)1b(tr/tr) mice results in tumor development. Because most of these cancers resembled trichilemmal carcinomas, we...
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