Article
Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter.
Cancer research - 15 Sept 2004
Xian Jian, Aitchison Alan, Bobrow Linda, Corbett Gerard, Pannell Richard, Rabbitts Terence, Rabbitts Pamela
Abstract excerpt
The DUTT1 gene is located on human chromosome 3, band p12, within a region of nested homozygous deletions in breast and lung tumors. It is therefore a candidate tumor suppressor gene in humans and is the homologue (ROBO1) of the Drosophila axonal guidance receptor gene, Roundabout. We have shown previously that mice with a targeted homozygous deletion within the Dutt1/Robo1 gene generally die at birth due to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.