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Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity.

The Journal of biological chemistry - 19 Feb 2010

North Simon J, Huang Hung-Hsiang, Sundaram Subha, Jang-Lee Jihye, Etienne A Tony, Trollope Alana, Chalabi Sara, Dell Anne, Stanley Pamela, Haslam Stuart M

Abstract excerpt

Identifying biological roles for mammalian glycans and the pathways by which they are synthesized has been greatly facilitated by investigations of glycosylation mutants of cultured cell lines and model organisms. Chinese hamster ovary (CHO) glycosylation mutants isolated on the basis of their lectin resistance have been particularly useful for glycosylation engineering of recombinant glycoproteins. To further...

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PMID: 19951948
DOI: 10.1074/jbc.M109.068353
PMCID: PMC2820803

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