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Article

Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.

Carcinogenesis - 1 Jun 2008

Suzuki Hideo, Morris Jeffrey S, Li Yanan, Doll Mark A, Hein David W, Liu Jun, Jiao Li, Hassan Manal M, Day Rena S, Bondy Melissa L, Abbruzzese James L, Li Donghui

Abstract excerpt

Aromatic amines, N-nitroso compounds and heterocyclic amines are suspected human pancreatic carcinogens. Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens. To test the hypothesis that genetic variations in carcinogen metabolism modify the risk of pancreatic cancer (PC), we investigated the effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18499698
DOI: 10.1093/carcin/bgn085
PMCID: PMC2443278

Genes

NAT1
NAT2

Provenance

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Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer.PMID 18499698Read ↗

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