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Article

Protective role for miR-9-5p in the fibrogenic transformation of human dermal fibroblasts

10 May 2016

Abstract excerpt

BACKGROUND: Excessive accumulation of extracellular matrix (ECM) proteins is the hallmark of fibrotic diseases, including skin fibrosis. This response relies on the activation of dermal fibroblasts that evolve into a pro-fibrogenic phenotype. One of the major players in this process is the cytokine transforming growth factor-β (TGF-β). MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally...

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PMID: 27274768
DOI: 10.1186/s13069-016-0044-2

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