KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription

Abstract excerpt

Background: Hypertrophic scars (HS) often occur after burns, surgery and extensive trauma. Krppel-like factor 4 (KLF4) is a member of the Krppel-like factor family, a group of conserved zinc finger transcription factors that regulate diverse cellular processes. KLF4 can participate in the regulation of fibrotic diseases in many organs, such as the lung, liver, and heart. However, the antifibrotic effect of KLF4...

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