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Article

Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts

11 Jan 2011

Abstract excerpt

INTRODUCTION: Increased levels of genes in the type I interferon (IFN) pathway have been observed in patients with systemic sclerosis (SSc), or scleroderma. How type I IFN regulates the dermal fibroblast and its participation in the development of dermal fibrosis is not known. We hypothesized that one mechanism by which type I IFN may contribute to dermal fibrosis is through upregulation of specific Toll-like...

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PMID: 21223583
DOI: 10.1186/ar3221

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