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Article

Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure.

Journal of virology - 1 Oct 2010

Kim Eun-Young, Bhattacharya Tanmoy, Kunstman Kevin, Swantek Peter, Koning Fransje A, Malim Michael H, Wolinsky Steven M

Abstract excerpt

Human apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G, hereinafter referred to as A3G) is an innate virus restriction factor that inhibits human immunodeficiency virus type 1 (HIV-1) replication and induces excessive deamination of cytidine residues in nascent reverse transcripts. To test the hypothesis that this enzyme can also help generate viral sequence diversification and the...

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Source

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Identifiers

PMID: 20660203
DOI: 10.1128/JVI.01223-10
PMCID: PMC2937764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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