Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis.

PloS one - 1 Jan 2012

Jackson Heather A, Hegle Andrew, Nazzari Hamed, Jegla Timothy, Accili Eric A

Abstract excerpt

Hyperpolarization-activated Cyclic Nucleotide (HCN) channels are voltage-gated cation channels and are critical for regulation of membrane potential in electrically active cells. To understand the evolution of these channels at the molecular level, we cloned and examined two of three HCN homologs of the urochordate Ciona intestinalis (ciHCNa and ciHCNb). ciHCNa is like mammalian HCNs in that it possesses similar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to CHO Cells
Share to Cricetinae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide-Gated Cation Channels

Share to Epitopes

Share to Glycosylation

Share to Oocytes

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 23133599
DOI: 10.1371/journal.pone.0047590
PMCID: PMC3487815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asymmetric divergence in structure and function of HCN channel duplicates in Ciona intestinalis.PMID 23133599Read ↗

Evolution and structural diversification of hyperpolarization-activated cyclic nucleotide-gated channel genes.Semantic proximity Read ↗

A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit.Semantic proximity Read ↗

Molecular evolution of the junctophilin gene familySemantic proximity Read ↗

NALCN/Cch1 channelosome subunits originated in early eukaryotes and are fully conserved in animals, fungi, and apusomonadsSemantic proximity Read ↗

Evolution and diversity of mammalian sodium channel genes.Semantic proximity Read ↗

Functional diversification of kir7.1 in cichlids accelerated by gene duplication.Semantic proximity Read ↗

The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways.Semantic proximity Read ↗

Tissue-specific N terminus of the HCN4 channel affects channel activation.Semantic proximity Read ↗

Gene structure evolution of the Na+-Ca2+ exchanger (NCX) family.Semantic proximity Read ↗

Structural basis for gating inhibition by the cytoplasmic domain in HCN1 channelsSemantic proximity Read ↗

Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family.Semantic proximity Read ↗

Exploiting the extraordinary genetic polymorphism of ciona for developmental genetics with whole genome sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.