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Article

Evolution and structural diversification of hyperpolarization-activated cyclic nucleotide-gated channel genes.

Physiological genomics - 11 May 2007

Jackson Heather A, Marshall Christian R, Accili Eric A

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated channel superfamily and play a critical role in cellular pace-making. Overall sequence conservation is high throughout the family, and channel functions are similar but not identical. Phylogenetic analyses are imperative to understand how these genes have evolved and to make informed comparisons of HCN structure...

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Identifiers

PMID: 17227887
DOI: 10.1152/physiolgenomics.00142.2006

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