Article
A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit.
The Journal of experimental biology - 1 Feb 2006
Salvador-Recatalà Vicenta, Gallin Warren J, Abbruzzese Jennifer, Ruben Peter C, Spencer Andrew N
Abstract excerpt
Voltage-gated ion channels of the Kv4 subfamily produce A-type currents whose properties are tuned by accessory subunits termed KChIPs, which are a family of Ca2+ sensor proteins. By modifying expression levels and the intrinsic biophysical properties of Kv4 channels, KChIPs modulate the excitability properties of neurons and myocytes. We studied how a Kv4 channel from a tunicate, the first branching clade of the...
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