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Article

TDP-43 skeins show properties of amyloid in a subset of ALS cases.

Acta neuropathologica - 1 Jan 2013

Robinson John L, Geser Felix, Stieber Anna, Umoh Mfon, Kwong Linda K, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q

Abstract excerpt

Aggregation of TDP-43 proteins to form intracellular inclusions is the primary pathology in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with TDP-43 inclusions (FTLD-TDP). Histologically, in the cerebral cortex and limbic regions of affected ALS and FTLD-TDP patients, these pathologies occur as a variety of cytoplasmic, neuritic and intranuclear TDP-43 inclusions. In the spinal...

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Identifiers

PMID: 23124365
DOI: 10.1007/s00401-012-1055-8
PMCID: PMC3536927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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