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Article

Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis.

Journal of the American Chemical Society - 3 Feb 2010

Chen Allan K-H, Lin Ryan Y-Y, Hsieh Eva Z-J, Tu Pang-Hsien, Chen Rita P-Y, Liao Tai-Yan, Chen Wenlung, Wang Chih-Hsien, Huang Joseph J-T

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) has been identified as the major ubiquitinated aggregates in the inclusion bodies in the patients of amyotrophic lateral sclerosis (ALS) since 2006 and become a crucial culprit for ALS and related motor neuron diseases. Recent literature has further indicated that the major components of these aggregates are hyper-phosphorylated TDP-43 C-terminus. In an effort to clarify the...

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Identifiers

PMID: 20055380
DOI: 10.1021/ja9066207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis.PMID 20055380Read ↗

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