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Article

Evidence That TDP-43 is Not the Major Ubiquitinated Target Within the Pathological Inclusions of Amyotrophic Lateral Sclerosis

1 Dec 2007

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the presence of various types of ubiquitinated inclusions in the cytoplasm of affected motor neurons. The identification of the ubiquitinated targets within these inclusions has represented a major challenge, as this may provide new gene candidates and/or clues to understanding the neurodegenerative mechanism(s)...

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PMID: 18090923
DOI: 10.1097/nen.0b013e31815c5edd

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Evidence That TDP-43 is Not the Major Ubiquitinated Target Within the Pathological Inclusions of Amyotrophic Lateral SclerosisPMID 18090923Read ↗

[TDP-43 proteinopathies: ALS and frontotemporal dementias].Semantic proximity Read ↗

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in miceSemantic proximity Read ↗

Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).Semantic proximity Read ↗

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TDP-43 Proteinopathies: Neurodegenerative Protein Misfolding Diseases without AmyloidosisSemantic proximity Read ↗

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral SclerosisSemantic proximity Read ↗

TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTDSemantic proximity Read ↗

TDP‐43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degenerationSemantic proximity Read ↗

TDP‐43 is consistently co‐localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutationsSemantic proximity Read ↗

The role of TDP-43 mislocalization in amyotrophic lateral sclerosisSemantic proximity Read ↗

Proteolytic processing of TAR DNA binding protein‐43 by caspases produces C‐terminal fragments with disease defining properties independent of progranulinSemantic proximity Read ↗

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosisSemantic proximity Read ↗

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