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Article

In vitro prion-like behaviour of TDP-43 in ALS

6 Sept 2016

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), and >95% of familial and sporadic cases involve the deposition of insoluble aggregated, phosphorylated and cleaved TDP-43 protein. Accumulating clinical and biological evidence now indicates that ALS bears a number of similarities to the prion diseases, with TDP-43 acting as a misfolded 'prion-like' protein demonstrating...

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PMID: 27590623
DOI: 10.1016/j.nbd.2016.08.007

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