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Article

Cdk11-cyclinL controls the assembly of the RNA polymerase II mediator complex.

Cell reports - 29 Nov 2012

Drogat Julie, Migeot Valérie, Mommaerts Elise, Mullier Caroline, Dieu Marc, van Bakel Harm, Hermand Damien

Abstract excerpt

The large Mediator (L-Mediator) is a general coactivator of RNA polymerase II transcription and is formed by the reversible association of the small Mediator (S-Mediator) and the kinase-module-harboring Cdk8. It is not known how the kinase module association/dissociation is regulated. We describe the fission yeast Cdk11-L-type cyclin pombe (Lcp1) complex and show that its inactivation alters the global expression...

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Identifiers

PMID: 23122962
DOI: 10.1016/j.celrep.2012.09.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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