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Mutations to A/Puerto Rico/8/34 PB1 gene improves seasonal reassortant influenza A virus growth kinetics.

Vaccine - 17 Dec 2012

Plant Ewan P, Liu Teresa M, Xie Hang, Ye Zhiping

Abstract excerpt

It is desirable for influenza vaccine virus strains to have phenotypes that include good growth and hemagglutinin (HA) protein yield. The quality of these characteristics varies among the vaccine viruses and is usually due to multigenic effects. Many influenza A virus vaccine viruses are made as reassortants of the high yield virus A/Puerto Rico/8/34 (PR/8) and a circulating seasonal virus. Co-infection of eggs...

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PMID: 23116694
DOI: 10.1016/j.vaccine.2012.10.060

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