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Article

Development of high-yield influenza A virus vaccine viruses.

Nature communications - 2 Sept 2015

Ping Jihui, Lopes Tiago J S, Nidom Chairul A, Ghedin Elodie, Macken Catherine A, Fitch Adam, Imai Masaki, Maher Eileen A, Neumann Gabriele, Kawaoka Yoshihiro

Abstract excerpt

Vaccination is one of the most cost-effective ways to prevent infection. Influenza vaccines propagated in cultured cells are approved for use in humans, but their yields are often suboptimal. Here, we screened A/Puerto Rico/8/34 (PR8) virus mutant libraries to develop vaccine backbones (defined here as the six viral RNA segments not encoding haemagglutinin and neuraminidase) that support high yield in cell...

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Share to Hemagglutinin Glycoproteins, Influenza Virus
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H5N1 Subtype

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Source

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Identifiers

PMID: 26334134
DOI: 10.1038/ncomms9148
PMCID: PMC4569720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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