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Article

Gene constellation of influenza A virus reassortants with high growth phenotype prepared as seed candidates for vaccine production.

PloS one - 1 Jan 2011

Fulvini Andrew A, Ramanunninair Manojkumar, Le Jianhua, Pokorny Barbara A, Arroyo Jennifer Minieri, Silverman Jeanmarie, Devis Rene, Bucher Doris

Abstract excerpt

BACKGROUND: Influenza A virus vaccines undergo yearly reformulations due to the antigenic variability of the virus caused by antigenic drift and shift. It is critical to the vaccine manufacturing process to obtain influenza A seed virus that is antigenically identical to circulating wild type (wt) virus and grows to high titers in embryonated chicken eggs. Inactivated influenza A seasonal vaccines are generated...

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Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza A virus

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Share to Polymorphism, Restriction Fragment Length

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Source

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Identifiers

PMID: 21695145
DOI: 10.1371/journal.pone.0020823
PMCID: PMC3113853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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