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Article

Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Dec 2012

Blevins James E, Moralejo Daniel H, Wolden-Hanson Tami H, Thatcher Brendan S, Ho Jacqueline M, Kaiyala Karl J, Matsumoto Kozo

Abstract excerpt

CCK is hypothesized to inhibit meal size by acting at CCK1 receptors (CCK1R) on vagal afferent neurons that innervate the gastrointestinal tract and project to the hindbrain. Earlier studies have shown that obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats, which carry a spontaneous null mutation of the CCK1R, are hyperphagic and obese. Recent findings show that rats with CCK1R-null gene on a Fischer 344...

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Identifiers

PMID: 23115121
DOI: 10.1152/ajpregu.00393.2012
PMCID: PMC3532586

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CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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