Article
Selective leptin insensitivity and alterations in female-reproductive patterns linked to hyperleptinemia during infancy.
PloS one - 1 Jan 2013
Schroeder Mariana, Kronfeld-Schor Noga, Weller Aron
Abstract excerpt
The dramatic increase in the prevalence of childhood obesity worldwide makes the investigation of its early developmental stages and effective prevention strategies an urgent issue. CCK1 deficient OLETF rats are a model of obesity previously used to study the early phases of this disorder. Here, we exposed wild type (LETO) females to an early obesogenic environment and genetically obese OLETF females to a lean...
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