Article
Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice.
Experimental diabetes research - 1 Jan 2011
de Leeuw van Weenen J E, Parlevliet E T, Schröder-van der Elst J P, van den Berg S A, Willems van Dijk K, Romijn J A, Pijl H
Abstract excerpt
High fat feeding induces a variety of obese and lean phenotypes in inbred rodents. Compared to Diet Resistant (DR) rodents, Diet Induced Obese (DIO) rodents are insulin resistant and have a reduced dopamine receptor D2 (DRD2) mediated tone. We hypothesized that this differing dopaminergic tone contributes to the distinct metabolic profiles of these animals. C57Bl6 mice were classified as DIO or DR based on their...
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