Article
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
The Journal of clinical investigation - 1 Aug 2003
Cota Daniela, Marsicano Giovanni, Tschöp Matthias, Grübler Yvonne, Flachskamm Cornelia, Schubert Mirjam, Auer Dorothee, Yassouridis Alexander, Thöne-Reineke Christa, Ortmann Sylvia, Tomassoni Federica, Cervino Cristina, Nisoli Enzo, Linthorst Astrid C E, Pasquali Renato, Lutz Beat, Stalla Günter K, Pagotto Uberto
Abstract excerpt
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1-/-) exhibited reduced spontaneous caloric intake and, as a consequence of reduced total fat mass, decreased body...
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