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Article

Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats.

PloS one - 1 Jan 2012

de Lartigue Guillaume, Barbier de la Serre Claire, Espero Elvis, Lee Jennifer, Raybould Helen E

Abstract excerpt

BACKGROUND AND AIMS: The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby increasing their sensitivity to CCK. In response to a chronic ingestion of a high fat diet, VAN develop leptin...

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Source

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Identifiers

PMID: 22412960
DOI: 10.1371/journal.pone.0032967
PMCID: PMC3296757

Genes

CCK
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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