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Article

Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors.

Endocrinology - 1 May 2006

Sutton Gregory M, Trevaskis James L, Hulver Matthew W, McMillan Ryan P, Markward Nathan J, Babin M Josephine, Meyer Emily A, Butler Andrew A

Abstract excerpt

Loss of brain melanocortin receptors (Mc3rKO and Mc4rKO) causes increased adiposity and exacerbates diet-induced obesity (DIO). Little is known about how Mc3r or Mc4r genotype, diet, and obesity affect insulin sensitivity. Insulin resistance, assessed by insulin and glucose tolerance tests, Ser(307) phosphorylation of insulin receptor substrate 1, and activation of protein kinase B, was examined in control and...

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Identifiers

PMID: 16469808
DOI: 10.1210/en.2005-1209
PMCID: PMC2735103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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