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Article

Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2004

Levin Barry E, Dunn-Meynell Ambrose A, Banks William A

Abstract excerpt

Rats selectively bred to develop diet-induced obesity (DIO) were compared with those bred to be diet resistant (DR) on a 31% fat high-energy diet with regard to their central leptin signaling and blood-brain barrier (BBB) transport. Peripheral leptin injection (15 mg/kg ip) into lean 4- to 5-wk-old rats produced 54% less anorexia in DIO than DR rats. DIO rats also had 21, 63, and 64% less leptin-induced...

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PMID: 12958061
DOI: 10.1152/ajpregu.00393.2003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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