Article
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation.
Infection and immunity - 1 Jan 2013
Ulland Tyler K, Janowski Ann M, Buchan Blake W, Faron Matthew, Cassel Suzanne L, Jones Bradley D, Sutterwala Fayyaz S
Abstract excerpt
Francisella tularensis is a Gram-negative bacterium and the causative agent of the disease tularemia. Escape of F. tularensis from the phagosome into the cytosol of the macrophage triggers the activation of the AIM2 inflammasome through a mechanism that is not well understood. Activation of the AIM2 inflammasome results in autocatalytic cleavage of caspase-1, resulting in the processing and secretion of...
Topics
- Animals
- Bacterial Vaccines
- Carbon-Nitrogen Ligases
- Caspase 1
- Folic Acid
- Francisella tularensis
- Inflammasomes
- Interleukin-18
- Interleukin-1beta
- Intramolecular Transferases
- Macrophage Activation
- Macrophages
- Mice