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Article

Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain.

Infection and immunity - 16 Jun 2021

Alqahtani Maha, Ma Zhuo, Fantone Kayla, Malik Meenakshi, Bakshi Chandra Shekhar

Abstract excerpt

Francisella tularensis is a facultative, intracellular, Gram-negative bacterium that causes a fatal disease known as tularemia. Due to its extremely high virulence, ease of spread by aerosolization, and potential to be used as a bioterror agent, F. tularensis is classified by the CDC as a tier 1 category A select agent. Previous studies have demonstrated the roles of the inflammasome sensors absent in melanoma 2...

Topics

Animals
Bacterial Vaccines
DNA-Binding Proteins
Disease Models, Animal
Francisella tularensis
Host-Pathogen Interactions
Immunity, Humoral
Immunization
Mice
Mice, Knockout
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NLR Family, Pyrin Domain-Containing 3 Protein

Tularemia

Vaccines, Attenuated

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 33875472
DOI: 10.1128/IAI.00134-21
PMCID: PMC8208512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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