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Exploitation of Host Cell Biology and Evasion of Immunity by Francisella Tularensis

1 Jan 2011

Abstract excerpt

Francisella tularensis is an intracellular bacterium that infects humans and many small mammals. During infection, F. tularensis replicates predominantly in macrophages but also proliferate in other cell types. Entry into host cells is mediate by various receptors. Complement-opsonized F. tularensis enters into macrophages by looping phagocytosis. Uptake is mediated in part by Syk, which may activate actin...

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PMID: 21687747
DOI: 10.3389/fmicb.2010.00145

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