IFN-β Mediates Suppression of IL-12p40 in Human Dendritic Cells following Infection with Virulent <i>Francisella tularensis</i>

Abstract excerpt

Active suppression of inflammation is a strategy used by many viral and bacterial pathogens, including virulent strains of the bacterium Francisella tularensis, to enable colonization and infection in susceptible hosts. In this study, we demonstrated that virulent F. tularensis strain SchuS4 selectively inhibits production of IL-12p40 in primary human cells via induction of IFN-β. In contrast to the attenuated...

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