Article
An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.
Antimicrobial agents and chemotherapy - 1 Jan 2013
Stokes Neil R, Baker Nicola, Bennett James M, Berry Joanne, Collins Ian, Czaplewski Lloyd G, Logan Alastair, Macdonald Rebecca, Macleod Leanne, Peasley Hilary, Mitchell Jeffrey P, Nayal Narendra, Yadav Anju, Srivastava Anil, Haydon David J
Abstract excerpt
The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have been reported to be potent and selective antistaphylococcal agents which exert their effects through the disruption of intracellular FtsZ function. Here, we report the further optimization of 3-methoxybenzamide derivatives towards a...
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