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Article

Doxorubicin inhibits E. coli division by interacting at a novel site in FtsZ.

The Biochemical journal - 1 Nov 2015

Panda Pragnya, Taviti Ashoka Chary, Satpati Suresh, Kar Mitali Madhusmita, Dixit Anshuman, Beuria Tushar Kant

Abstract excerpt

The increase in antibiotic resistance has become a major health concern in recent times. It is therefore essential to identify novel antibacterial targets as well as discover and develop new antibacterial agents. FtsZ, a highly conserved bacterial protein, is responsible for the initiation of cell division in bacteria. The functions of FtsZ inside cells are tightly regulated and any perturbation in its functions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26285656
DOI: 10.1042/BJ20150467

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