FtsZ as a novel target for antibiotics development: Promises and challenges

Abstract excerpt

Filamenting temperature-sensitive mutant Z (FtsZ), a protein essential for bacterial cell division, is highly conserved across bacterial species but absent in humans, positioning it as a strategic target for the development of antibiotics. Significant efforts to identify FtsZ inhibitors— via biochemical assays ( e.g. , GTPase activity) and cellular approaches ( e.g. , immunofluorescence)—have yielded over 100...

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