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Article

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.

Science (New York, N.Y.) - 19 Sept 2008

Haydon David J, Stokes Neil R, Ure Rebecca, Galbraith Greta, Bennett James M, Brown David R, Baker Patrick J, Barynin Vladimir V, Rice David W, Sedelnikova Sveta E, Heal Jonathan R, Sheridan Joseph M, Aiwale Sachin T, Chauhan Pramod K, Srivastava Anil, Taneja Amit, Collins Ian, Errington Jeff, Czaplewski Lloyd G

Abstract excerpt

FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian beta-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of small synthetic antibacterials, exemplified by PC190723, which inhibits FtsZ and prevents cell division. P...

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Source

Identifiers

PMID: 18801997
DOI: 10.1126/science.1159961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18801997-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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