Article
A benzamide-dependent ftsZ mutant reveals residues crucial for Z-ring assembly.
Molecular microbiology - 1 Mar 2016
Adams David William, Wu Ling Juan, Errington Jeff
Abstract excerpt
In almost all bacteria, cell division is co-ordinated by the essential tubulin homologue FtsZ and represents an attractive but as yet unexploited target for new antibiotics. The benzamides, e.g. PC190723, are potent FtsZ inhibitors that have the potential to yield an important new class of antibiotic. However, the evolution of resistance poses a challenge to their development. Here we show that a collection of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.