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Article

Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

Biochimie - 1 Oct 2013

Kaul Malvika, Zhang Yongzheng, Parhi Ajit K, Lavoie Edmond J, Tuske Steve, Arnold Eddy, Kerrigan John E, Pilch Daniel S

Abstract excerpt

New antibiotics with novel mechanisms of action are urgently needed to overcome the growing bacterial resistance problem faced by clinicians today. PC190723 and related compounds represent a promising new class of antibacterial compounds that target the essential bacterial cell division protein FtsZ. While this family of compounds exhibits potent antistaphylococcal activity, they have poor activity against...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23806423
DOI: 10.1016/j.biochi.2013.06.010
PMCID: PMC5508555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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