Article
Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.
Science translational medicine - 21 Mar 2012
Tan Christopher M, Therien Alex G, Lu Jun, Lee Sang H, Caron Alexandre, Gill Charles J, Lebeau-Jacob Christian, Benton-Perdomo Liliana, Monteiro João M, Pereira Pedro M, Elsen Nathaniel L, Wu Jin, Deschamps Kathleen, Petcu Mihai, Wong Simon, Daigneault Etienne, Kramer Susanne, Liang Lianzhu, Maxwell Eugene, Claveau David, Vaillancourt John, Skorey Kathryn, Tam John, Wang Hao, Meredith Timothy C, Sillaots Susan, Wang-Jarantow Lisa, Ramtohul Yeeman, Langlois Eric, Landry France, Reid John C, Parthasarathy Gopal, Sharma Sujata, Baryshnikova Anastasia, Lumb Kevin J, Pinho Mariana G, Soisson Stephen M, Roemer Terry
Abstract excerpt
Despite the need for new antibiotics to treat drug-resistant bacteria, current clinical combinations are largely restricted to β-lactam antibiotics paired with β-lactamase inhibitors. We have adapted a Staphylococcus aureus antisense knockdown strategy to genetically identify the cell division Z ring components-FtsA, FtsZ, and FtsW-as β-lactam susceptibility determinants of methicillin-resistant S. aureus (MRSA)....
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