Article
Interleukin-1 gene cluster variants and abdominal aortic aneurysms.
Thrombosis and haemostasis - 1 Sept 2005
Marculescu Rodrig, Sodeck Gottfried, Domanovits Hans, Hobusch Gerhard, Exner Markus, Heinzl Harald, Huber Kurt, Mannhalter Christine, Minar Erich, Wagner Oswald, Schillinger Martin
Abstract excerpt
Inflammation is a key factor in the pathogenesis of abdominal aortic aneurysms (AAA). Interleukin 1 (IL-1), a fundamental regulator of the inflammatory cascade, has been shown to be involved in this process. Several functional polymorphisms in the IL-1 gene cluster are known. In this matched case-control study, we investigated a potential association between six genetic variants in IL-1 and IL-1 receptor...
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