Article

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates

2018-09-27

Abstract excerpt

<h4>Background</h4> The Asp358Ala variant (rs2228145; A>C) in the interleukin-6 receptor ( IL6R ) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R -Asp358Ala variant and AAA growth, and to assess the effect of blocking the IL-6 signalling pathway in mouse models...

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Literature Corpus work: 3d37e0ff-e5ef-57ed-bf40-17cf6d95a0ce
DOI: 10.1101/428516

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