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Article

High expression of TNF alpha is associated with -308 and -238 TNF alpha polymorphisms in knee osteoarthritis.

Clinical and experimental medicine - 1 Feb 2014

Muñoz-Valle José Francisco, Oregón-Romero Edith, Rangel-Villalobos Héctor, Martínez-Bonilla Gloria Esther, Castañeda-Saucedo Eduardo, Salgado-Goytia Lorenzo, Leyva-Vázquez Marco Antonio, Illades-Aguiar Berenice, Alarcón-Romero Luz del Carmen, Espinoza-Rojo Mónica, Parra-Rojas Isela

Abstract excerpt

Knee osteoarthritis (OA) is a common chronic degenerative disease characterized by the loss of articular cartilage components due to an imbalance between extracellular matrix destruction and repair. The proinflammatory cytokines involved in OA, TNFα and IL1β, are considered the major implicated. The aim of this study was to investigate the relationship between TNFα -308 and -238 polymorphisms with messenger RNA...

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PMID: 23108479
DOI: 10.1007/s10238-012-0216-3

Genes

TNF
ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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